SNAP iN, SNAP oUT—SNAREs at ER-PM Contact Sites

PERK interacts with FLNA to regulate ER-PM contact sites

Snap Code:

This Chapter covers the emissions of airborne particulate matter (PM) from road transport which are due to vehicle tyre and brake wear (SNAP code 070700) and road surface wear (SNAP code 070800). PM emissions from vehicle exhaust are not included. The focus is on primary non-exhaust particles in other words those particles emitted directly as a result of the wear of surfaces and not those resul...

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis. Previous work demonstrated that the highly conserved yeast Ltc/Lam sterol transporters localize and function at ER MCSs. Our analysis of the human family members, GRAMD1a and GRAMD2a, demonstrates that they are ER-PM MCS pr...

[Predictive value of SNAP and SNAP-PE for neonatal mortality]

OBJECTIVE: To evaluate the Score for Neonatal Acute Physiology and the Score for Neonatal Acute Physiology Perinatal Extension as neonatal mortality predictors in our neonatal intensive care unit, and to compare their results. METHODS: All newborn infants admitted to our neonatal intensive care unit from March 1997 through December 1998 were prospectively evaluated just at completion of 24 hour...

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

Sterol traffic between the endoplasmic reticulum (ER) and plasma membrane (PM) is a fundamental cellular process that occurs by a poorly understood non-vesicular mechanism. We identified a novel, evolutionarily diverse family of ER membrane proteins with StART-like lipid transfer domains and studied them in yeast. StART-like domains from Ysp2p and its paralog Lam4p specifically bind sterols, an...